IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation.

ABSTRACT: Antibody replacement therapy for patients with antibody deficiencies contains only IgG. As a result, concurrent IgM and IgA deficiency present in a large proportion of antibody deficient patients persists. Especially patients with IgM deficiency remain at risk for recurrent infections of the gastrointestinal and respiratory tract. The lack of IgM in the current IgG replacement therapy is likely to contribute to the persistence of these mucosal infections because this antibody class is especially important for complement activation on the mucosal surface. We evaluated whether supplementation with IgM increased serum bactericidal capacity in vitro. Serum was collected from a patient with agammaglobulinemia and supplemented with purified serum IgM to normal levels. Antibody and complement dep

SUBMITTER: Langereis JD 

PROVIDER: S-EPMC5840230 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature