Genetic association between HER2 and ESR2 polymorphisms and ovarian cancer: a meta-analysis.

ABSTRACT:

Objective

The estrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER2) each play an important role in female cancers. This study aimed to investigate the genetic association between three common single nucleotide polymorphisms (SNPs) and the risk of ovarian cancer. The SNPs investigated in this study were ESR2 rs1271572 and rs3020450 and HER2 rs1801200.

Methods

In this study, databases were electronically searched in a meta-analysis. Databases used were PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Cochrane library. Case-control studies on the association between ESR2 and HER2 polymorphisms were selected according to inclusion and exclusion standard. Articles were evaluated for quality, and data were extracted.

Results</

SUBMITTER: Tang L 

PROVIDER: S-EPMC5840274 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature