¹H NMR-based metabolomics reveals the effect of maternal habitual dietary patterns on human amniotic fluid profile.

ABSTRACT: Maternal diet may influence offspring's health, even within well-nourished populations. Amniotic fluid (AF) provides a rational compartment for studies on fetal metabolism. Evidence in animal models indicates that maternal diet affects AF metabolic profile; however, data from human studies are scarce. Therefore, we have explored whether AF content may be influenced by maternal diet, using a validated food-frequency questionnaire and implementing NMR-based metabolomics. Sixty-five AF specimens, from women undergoing second-trimester amniocentesis for prenatal diagnosis, were analysed. Complementary, maternal serum and urine samples were profiled. Hierarchical cluster analysis identified 2 dietary patterns, cluster 1 (C1, n = 33) and cluster 2 (C2, n = 32). C1 was characterized by significan

SUBMITTER: Fotiou M 

PROVIDER: S-EPMC5840288 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature