Online proton therapy monitoring: clinical test of a Silicon-photodetector-based in-beam PET.

ABSTRACT: Particle therapy exploits the energy deposition pattern of hadron beams. The narrow Bragg Peak at the end of range is a major advantage but range uncertainties can cause severe damage and require online verification to maximise the effectiveness in clinics. In-beam Positron Emission Tomography (PET) is a non-invasive, promising in-vivo technique, which consists in the measurement of the β+ activity induced by beam-tissue interactions during treatment, and presents the highest correlation of the measured activity distribution with the deposited dose, since it is not much influenced by biological washout. Here we report the first clinical results obtained with a state-of-the-art in-beam PET scanner, with on-the-fly reconstruction of the activity distribution during irradiation. An automated

SUBMITTER: Ferrero V 

PROVIDER: S-EPMC5840345 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature