Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis.

ABSTRACT: The aim of this meta-analysis is to evaluate the analgesic effects of intra-articular dexmedetomidine (DEX) in arthroscopic knee surgery. A comprehensive literature search was conducted to identify randomized controlled trials (RCTs) comparing intra-articular DEX versus control for postoperative analgesia in knee arthroscopy. Trial sequential analysis (TSA) was applied to determine the reliability of the evidence. Twelve RCTs including 594 patients met the eligibility criteria. DEX treatment significantly improved postoperative pain outcomes, with weighted mean differences (95% confidence interval) between the DEX and control groups of -1.57 (-1.94 to -1.20, P < 0.00001) for pain scores at rest at postoperative 1 h, -8.54 mg (-11.96 to -5.13, P < 0.00001) for morphine-equivalents at postop

SUBMITTER: Peng K 

PROVIDER: S-EPMC5840390 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature