Increased Glutamine Consumption in Cisplatin-Resistant Cells Has a Negative Impact on Cell Growth.

ABSTRACT: The emergence of drug-resistant subclones remains the primary reason for tumor treatment failure. Some theories suggest that drug-resistant cell growth can be suppressed by drug-sensitive cells because resistant cells are less fit than sensitive cells in the absence of drug. We investigated fitness differences and their underlying mechanisms in cisplatin (ddp)-resistant cells and parental cells. We found that glutamine (Gln) consumption was substantially higher in ddp-resistant cells than that in sensitive cells, indicating that significantly fewer ddp-resistant cells than sensitive cells could be generated under the same Gln conditions. Interestingly, the antioxidant capacity of ddp-resistant cells was also significantly enhanced and was directly related to the presence of Gln. Then, we f

SUBMITTER: Duan G 

PROVIDER: S-EPMC5840399 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature