Gene-by-environment interactions in urban populations modulate risk phenotypes.

ABSTRACT: Uncovering the interaction between genomes and the environment is a principal challenge of modern genomics and preventive medicine. While theoretical models are well defined, little is known of the G × E interactions in humans. We used an integrative approach to comprehensively assess the interactions between 1.6 million data points, encompassing a range of environmental exposures, health, and gene expression levels, coupled with whole-genome genetic variation. From ∼1000 individuals of a founder population in Quebec, we reveal a substantial impact of the environment on the transcriptome and clinical endophenotypes, overpowering that of genetic ancestry. Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancest

SUBMITTER: Fave MJ 

PROVIDER: S-EPMC5840419 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature