Development of a Low-cost, Comprehensive Recording System for Circadian Rhythm Behavior.

ABSTRACT: Circadian rhythm is defined as a 24-hour biological oscillation, which persists even without any external cues but also can be re-entrained by various environmental cues. One of the widely accepted circadian rhythm behavioral experiment is measuring the wheel-running activity (WRA) of rodents. However, the price for commercially available WRA recording system is not easily affordable for researchers due to high-cost implementation of sensors for wheel rotation. Here, we developed a cost-effective and comprehensive system for circadian rhythm recording by measuring the house-keeping activities (HKA). We have monitored animal's HKA as electrical signal by simply connecting animal housing cage with a standard analog/digital converter: input to the metal lid and ground to the metal grid floor.

SUBMITTER: Kwon J 

PROVIDER: S-EPMC5840463 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature