Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts.

ABSTRACT:

Background

Atopic dermatitis (AD) is a prevalent disease with variable natural history. Longitudinal birth cohort studies provide an opportunity to define subgroups on the basis of disease trajectories, which may represent different genetic and environmental pathomechanisms.

Objectives

We sought to investigate the existence of distinct longitudinal phenotypes of AD and test whether these findings are reproducible in 2 independent cohorts.

Methods

The presence of AD was examined in 2 birth cohort studies including 9894 children from the United Kingdom (ALSPAC) and 3652 from the Netherlands (PIAMA). AD was defined by parental report of a typical itchy and/or flexural rash. Longitudinal latent class analysis was used to investigate patterns of AD from birth to the age of

SUBMITTER: Paternoster L 

PROVIDER: S-EPMC5840507 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature