Identification of potential therapeutic targets in prostate cancer through a cross-species approach.

ABSTRACT: Genetically engineered mouse models of cancer can be used to filter genome-wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development and progression. In this study, we have generated RNAseq data from tumours arising in two established mouse models of prostate cancer, PB-Cre/Pten^loxP/loxP and p53^loxP/loxPRb^loxP/loxP, and integrated this with published human prostate cancer expression data to pinpoint cancer-associated gene expression changes that are conserved between the two species. To identify potential therapeutic targets, we then filtered this information for genes that are either known or predicted to be druggable. Using this approach, we revealed a

SUBMITTER: Jurmeister S 

PROVIDER: S-EPMC5840539 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature