Investigating a multigene prognostic assay based on significant pathways for Luminal A breast cancer through gene expression profile analysis.

ABSTRACT: The present study aimed to investigate potential recurrence-risk biomarkers based on significant pathways for Luminal A breast cancer through gene expression profile analysis. Initially, the gene expression profiles of Luminal A breast cancer patients were downloaded from The Cancer Genome Atlas database. The differentially expressed genes (DEGs) were identified using a Limma package and the hierarchical clustering analysis was conducted for the DEGs. In addition, the functional pathways were screened using Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses and rank ratio calculation. The multigene prognostic assay was exploited based on the statistically significant pathways and its prognostic function was tested using train set and verified using the gene expression data

SUBMITTER: Gao H 

PROVIDER: S-EPMC5840762 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature