A sophisticated, differentiated Golgi in the ancestor of eukaryotes.

ABSTRACT: BACKGROUND:The Golgi apparatus is a central meeting point for the endocytic and exocytic systems in eukaryotic cells, and the organelle's dysfunction results in human disease. Its characteristic morphology of multiple differentiated compartments organized into stacked flattened cisternae is one of the most recognizable features of modern eukaryotic cells, and yet how this is maintained is not well understood. The Golgi is also an ancient aspect of eukaryotes, but the extent and nature of its complexity in the ancestor of eukaryotes is unclear. Various proteins have roles in organizing the Golgi, chief among them being the golgins. RESULTS:We address Golgi evolution by analyzing genome sequences from organisms which have lost stacked cisternae as a feature of their Golgi and those that have

SUBMITTER: Barlow LD 

PROVIDER: S-EPMC5840792 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature