SABRE-Relay: A Versatile Route to Hyperpolarization.

ABSTRACT: Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H₂) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine, and pyrazine). The substrate then reacts reversibly with [Pt(OTf)₂(bis-diphenylphosphinopropane)] by displacing OTf^- to form [Pt(OTf)(sub)(bis-diphenylphosphinopropane)]OTf. The ³¹P NMR signals of these metal complexes prove to be enhanced when the substrate possesses an accessible singlet state or long-lived Zeeman polarization. In the case of pyrazine, the corresponding ³¹P signal was 105 ± 8 times larger than expected, which equated to an 8 h reduction in total scan time for an equivalent signal-to-noise ratio under

SUBMITTER: Roy SS 

PROVIDER: S-EPMC5840861 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature