Microbleed and microinfarct detection in amyloid angiopathy: a high-resolution MRI-histopathology study.

ABSTRACT: Cerebral amyloid angiopathy is a common neuropathological finding in the ageing human brain, associated with cognitive impairment. Neuroimaging markers of severe cerebral amyloid angiopathy are cortical microbleeds and microinfarcts. These parenchymal brain lesions are considered key contributors to cognitive impairment. Therefore, they are important targets for therapeutic strategies and may serve as surrogate neuroimaging markers in clinical trials. We aimed to gain more insight into the pathological basis of magnetic resonance imaging-defined microbleeds and microinfarcts in cerebral amyloid angiopathy, and to explore the pathological burden that remains undetected, by using high and ultra-high resolution ex vivo magnetic resonance imaging, as well as detailed histological sampling. Bra

SUBMITTER: van Veluw SJ 

PROVIDER: S-EPMC5840880 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature