Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala.

ABSTRACT: Structural magnetic resonance imaging data are frequently analysed to reveal morphological changes of the human brain in dementia. Most contemporary imaging biomarkers are scalar values, such as the volume of a structure, and may miss the localized morphological variation of early presymptomatic disease progression. Neuroanatomical shape descriptors, however, can represent complex geometric information of individual anatomical regions and may demonstrate increased sensitivity in association studies. Yet, they remain largely unexplored. In this article, we introduce a novel technique to study shape asymmetries of neuroanatomical structures across subcortical and cortical brain regions. We demonstrate that neurodegeneration of subcortical structures in Alzheimer's disease is not symmetric. T

SUBMITTER: Wachinger C 

PROVIDER: S-EPMC5840883 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature