Connectomic correlates of response to treatment in first-episode psychosis.

ABSTRACT: Connectomic approaches using diffusion tensor imaging have contributed to our understanding of brain changes in psychosis, and could provide further insights into the neural mechanisms underlying response to antipsychotic treatment. We here studied the brain network organization in patients at their first episode of psychosis, evaluating whether connectome-based descriptions of brain networks predict response to treatment, and whether they change after treatment. Seventy-six patients with a first episode of psychosis and 74 healthy controls were included. Thirty-three patients were classified as responders after 12 weeks of antipsychotic treatment. Baseline brain structural networks were built using whole-brain diffusion tensor imaging tractography, and analysed using graph analysis and ne

SUBMITTER: Crossley NA 

PROVIDER: S-EPMC5841056 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature