Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants.

ABSTRACT: Primary progressive aphasia is a syndrome characterized by progressive loss of language abilities with three main phenotypic clinical presentations, including logopenic, non-fluent/agrammatic, and semantic variants. Previous imaging studies have shown unique anatomic impacts within language networks in each variant. However, direct measures of spontaneous neuronal activity and functional integrity of these impacted neural networks in primary progressive aphasia are lacking. The aim of this study was to characterize the spatial and temporal patterns of resting state neuronal synchronizations in primary progressive aphasia syndromes. We hypothesized that resting state brain oscillations will show unique deficits within language network in each variant of primary progressive aphasia. We exami

SUBMITTER: Ranasinghe KG 

PROVIDER: S-EPMC5841154 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature