Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease.
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SUBMITTER: Rorabaugh JM
PROVIDER: S-EPMC5841201 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease.
Rorabaugh Jacki M JM Chalermpalanupap Termpanit T Botz-Zapp Christian A CA Fu Vanessa M VM Lembeck Natalie A NA Cohen Robert M RM Weinshenker David D
Brain : a journal of neurology 20171101 11
See Grinberg and Heinsen (doi:10.1093/brain/awx261) for a scientific commentary on this article. Clinical evidence suggests that aberrant tau accumulation in the locus coeruleus and noradrenergic dysfunction may be a critical early step in Alzheimer’s disease progression. Yet, an accurate preclinical model of these phenotypes that includes early pretangle tau accrual in the locus coeruleus, loss of locus coeruleus innervation and deficits locus coeruleus/norepinephrine modulated behaviours, doe ...[more]
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