Seizure onset zone localization using postictal hypoperfusion detected by arterial spin labelling MRI.

ABSTRACT: Neurological dysfunction following epileptic seizures is a well-recognized phenomenon. Several potential mechanisms have been suggested to explain postictal dysfunction, with alteration in cerebral blood flow being one possibility. These vascular disturbances may be long lasting and localized to brain areas involved in seizure generation and propagation, as supported by both animal and human studies. Therefore, measuring perfusion changes in the postictal period may help localize the seizure onset zone. Arterial spin labelling is a non-invasive, rapid and reproducible magnetic resonance imaging technique that measures cerebral perfusion. To this end, we measured postictal perfusion in patients with drug resistant focal epilepsy who were admitted to our seizure-monitoring unit for presurgic

SUBMITTER: Gaxiola-Valdez I 

PROVIDER: S-EPMC5841204 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature