Image-Guided Focused-Ultrasound CNS Molecular Delivery: An Implementation via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging.

ABSTRACT: Focused ultrasound (FUS) exposure with microbubbles can transiently open the blood-brain barrier (BBB) to deliver therapeutic molecules into CNS tissues. However, delivered molecular distribution/concentration at the target need to be controlled. Dynamic Contrast-Enhanced Magnetic-Resonance Imaging (DCE-MRI) is a well-established protocol for monitoring the pharmacokinetic/pharmacodynamic behavior of FUS-BBB opening. This study investigates the feasibility of using DCE-MRI to estimate molecular CNS penetration under various exposure conditions and molecule sizes. In the 1^st stage, a relationship among the imaging index K_trans, exposure level and molecular size was calibrated and established. In the 2^nd stage, various exposure levels and distinct molecules w

SUBMITTER: Chai WY 

PROVIDER: S-EPMC5841286 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature