Increased identification of novel variants in type 2 diabetes, birth weight and their pleiotropic loci.

ABSTRACT:

Background

Clinical and epidemiological findings point to an association between type 2 diabetes (T2D) and low birth weight. However, the nature of the relationship is largely unknown. The aim of this study was to identify novel single nucleotide polymorphisms (SNPs) in T2D and birth weight, and their pleiotropic loci.

Methods

A pleiotropy-informed conditional false discovery rate (cFDR) method was applied to two independent genome-wide association studies (GWAS) summary statistics of T2D (n = 149 821) and birth weight (n = 26 836).

Results

A conditional Q-Q plot showed strong enrichment of genetic variants in T2D conditioned on different levels of association with birth weight. 133 T2D-associated SNPs, including 120 novel SNPs, were identified with a significance thr

SUBMITTER: Zeng CP 

PROVIDER: S-EPMC5841537 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature