Combined effects of smoking and HPV16 in oropharyngeal cancer.

ABSTRACT:

Background

Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.

Methods

Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multi-centre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.

Results

Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositi

SUBMITTER: Anantharaman D 

PROVIDER: S-EPMC5841602 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature