Birthweight, childhood growth and left ventricular structure at age 60-64 years in a British birth cohort study.

ABSTRACT:

Background

High left ventricular mass (LVM) is an independent predictor of cardiovascular disease and mortality, but information relating LVM in older age to growth in early life is limited. We assessed the relationship of birthweight, height and body mass index (BMI) and overweight across childhood and adolescence with later life left ventricular (LV) structure.

Methods

We used data from the MRC National Survey of Health and Development (NSHD) on men and women born in 1946 in Britain and followed up ever since. We use regression models to relate prospective measures of birthweight and height and BMI from ages 2-20 years to LV structure at 60-64 years.

Results

Positive associations of birthweight with LVM and LV end diastolic volume (LVEDV) at 60-64 years were largely

SUBMITTER: Hardy R 

PROVIDER: S-EPMC5841632 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature