Augmented frontal cortex diacylglycerol levels in Parkinson's disease and Lewy Body Disease.

ABSTRACT:

Background

Research from our laboratory, and that of other investigators, has demonstrated augmented levels of diacylglycerols (DAG) in the frontal cortex and plasma of subjects with Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). We have extended these observations to investigate the frontal cortex of subjects with Parkinson's disease (PD) and Lewy Body Disease (LBD), with and without coexisting pathologic features of AD.

Methods/principal findings

Utilizing a high-resolution mass spectrometry analytical platform, we clearly demonstrate that DAG levels are significantly increased in the frontal cortex of subjects with PD, LBD with intermediate neocortical AD neuropathology, and in LBD with established neocortical AD neuropathology. In the case of the PD cohort

SUBMITTER: Wood PL 

PROVIDER: S-EPMC5841652 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature