Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life.

ABSTRACT:

Background

The placenta is the central regulator of maternal and fetal interactions. Perturbations of placental structure and function have been associated with adverse neurodevelopmental outcomes later in life. Placental CpG methylation represents an epigenetic modification with the potential to impact placental function, fetal development and child health later in life.

Study design

Genome-wide placental CpG methylation levels were compared between spontaneous versus indicated deliveries from extremely preterm births (EPTBs) (n = 84). The association between the identified differentially methylated CpG sites and neurocognitive outcome at ten years of age was then evaluated.

Results

Spontaneous EPTB was associated with differential CpG methylation levels in 250 CpG s

SUBMITTER: Tilley SK 

PROVIDER: S-EPMC5841757 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature