Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats.

ABSTRACT: High capacity and low capacity running rats, HCR and LCR respectively, have been bred to represent two extremes of running endurance and have recently demonstrated disparities in fuel usage during transient aerobic exercise. HCR rats can maintain fatty acid (FA) utilization throughout the course of transient aerobic exercise whereas LCR rats rely predominantly on glucose utilization. We hypothesized that the difference between HCR and LCR fuel utilization could be explained by a difference in mitochondrial density. To test this hypothesis and to investigate mechanisms of fuel selection, we used a constraint-based kinetic analysis of whole-body metabolism to analyze transient exercise data from these rats. Our model analysis used a thermodynamically constrained kinetic framework that accoun

SUBMITTER: Moxley MA 

PROVIDER: S-EPMC5841818 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature