Prenatal and infant paracetamol exposure and development of asthma: the Norwegian Mother and Child Cohort Study.

ABSTRACT:

Background

Paracetamol exposure has been positively associated with asthma development. The relative importance of prenatal vs infant exposure and confounding by indication remains elusive. We examined the association of prenatal and infant (first 6 months) paracetamol exposure with asthma development while addressing confounding by indication.

Methods

We used information from the Norwegian Mother and Child Cohort Study, including 53169 children for evaluation of current asthma at 3 years, 25394 for current asthma at 7 years and 45607 for dispensed asthma medications at 7 years in the Norwegian Prescription Database. We calculated adjusted relative risks (adj. RR) and 95% confidence intervals (CI) using log-binomial regression.

Results

There were independent modest as

SUBMITTER: Magnus MC 

PROVIDER: S-EPMC5841883 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature