Challenging Assumptions About African American Participation in Alzheimer Disease Trials.

ABSTRACT:

Objective

The authors investigated potential effects of increased African American participation in Alzheimer disease (AD) and mild cognitive impairment (MCI) clinical trials by examining differences in comorbid conditions and treatment outcome affecting trial design.

Methods

Using a meta-database of 18 studies from the Alzheimer's Disease Cooperative Study and the Alzheimer's Disease Neuroimaging Initiative, a cohort of 5,164 subjects were included for whom there were baseline demographic data and information on comorbid disorders, grouped by organ system. Meta-analysis was used to compare prevalence of comorbidities, dropouts, and rates of change on the cognitive subscale of the Alzheimer's Disease Assessment Scale by race. Clinical trial scenarios similar to recent therap

SUBMITTER: Kennedy RE 

PROVIDER: S-EPMC5842064 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature