Fibrosis in ulcerative colitis is directly linked to severity and chronicity of mucosal inflammation.

ABSTRACT: BACKGROUND:Fibrosis in ulcerative colitis has remained largely unexplored despite its clinical implications. AIMS:This cross-sectional study was aimed at characterising the presence, anatomical location and degree of ulcerative colitis-associated fibrosis and its possible link to clinical parameters. METHODS:Seven hundred and six individual tissue cross-sections derived every 10 cm along the length of 89 consecutive Ulcerative colitis colectomy specimens were examined and compared to Crohn's disease colitis, diverticular disease and uninvolved areas from colorectal cancer patients. Degree of inflammation, fibrosis and morphometric measurements of all layers of the intestinal wall were evaluated. Three gastrointestinal pathologists independently assessed colon sections stained with haematox

SUBMITTER: Gordon IO 

PROVIDER: S-EPMC5842117 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature