Chromatin organisation and cancer prognosis: a pan-cancer study.

ABSTRACT:

Background

Chromatin organisation affects gene expression and regional mutation frequencies and contributes to carcinogenesis. Aberrant organisation of DNA has been correlated with cancer prognosis in analyses of the chromatin component of tumour cell nuclei using image texture analysis. As yet, the methodology has not been sufficiently validated to permit its clinical application. We aimed to define and validate a novel prognostic biomarker for the automatic detection of heterogeneous chromatin organisation.

Methods

Machine learning algorithms analysed the chromatin organisation in 461 000 images of tumour cell nuclei stained for DNA from 390 patients (discovery cohort) treated for stage I or II colorectal cancer at the Aker University Hospital (Oslo, Norway). The resulting

SUBMITTER: Kleppe A 

PROVIDER: S-EPMC5842159 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature