Assessment of TANK-binding kinase 1 as a therapeutic target in cancer.

ABSTRACT: TANK-binding kinase 1 (TBK1) is central to multiple biological processes that promote tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival signaling. TBK1 is well studied and most known for its function in innate immunity. However, the serine threonine protein kinase received significant attention as a synthetic lethal partner and effector of the major oncogene, RAS. This review summarizes newly identified cancer promoting functions of TBK1 and evaluates the therapeutic potential of targeting TBK1 in cancer.

SUBMITTER: Cruz VH 

PROVIDER: S-EPMC5842199 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature