Prospective blinded surveillance screening of Swedish women with increased hereditary risk of breast cancer.

ABSTRACT: PURPOSE:To evaluate the sensitivity and specificity of different screening modalities in women with a family history of breast cancer. METHODS:Our blinded, prospective, comparative cohort analysis included three types of screening, mammography, ultrasound, and clinical breast examination once per year for 6 years. Eligible patients for this study were healthy women with ≥ 17% lifetime risk of breast cancer or with a mutation in BRCA1 or BRCA2. RESULTS:A total of 632 women were screened between 2002 and 2012 (each for 6 years). During the study, 30 women were diagnosed with breast cancer, with 10 of these diagnoses occurring between screening visits, and six of the 10 diagnosed women were gene carriers. The clinical presentation for the women diagnosed with breast cancer was followed until

SUBMITTER: Liljegren A 

PROVIDER: S-EPMC5842249 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature