Cognitive and psychopathology correlates of brain white/grey matter structure in severely psychotic schizophrenic inpatients.

ABSTRACT: The brain structural correlates of cognitive and psychopathological symptoms within the active phase in severely psychotic schizophrenic inpatients have been rarely investigated. Twenty-eight inpatients with a DSM-5 diagnosis of Schizophrenia (SZ), admitted for acute psychotic decompensation, were assessed through a comprehensive neuropsychological and psychopathological battery. All patients underwent a high-resolution T1-weighted magnetic resonance imaging investigation. Increased psychotic severity was related to reduced grey matter volumes in the medial portion of the right superior frontal cortex, the superior orbitofrontal cortex bilaterally and to white matter volume reduction in the medial portion of the left superior frontal area. Immediate verbal memory performance was related to

SUBMITTER: Banaj N 

PROVIDER: S-EPMC5842307 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature