Establishing pathological cut-offs for lateral ventricular volume expansion rates.

ABSTRACT:

Background

A percent brain volume change (PBVC) cut-off of -0.4% per year has been proposed to distinguish between pathological and physiological changes in multiple sclerosis (MS). Unfortunately, standardized PBVC measurement is not always feasible on scans acquired outside research studies or academic centers. Percent lateral ventricular volume change (PLVVC) is a strong surrogate measure of PBVC, and may be more feasible for atrophy assessment on real-world scans. However, the PLVVC rate corresponding to the established PBVC cut-off of -0.4% is unknown.

Objective

To establish a pathological PLVVC expansion rate cut-off analogous to -0.4% PBVC.

Methods

We used three complementary approaches. First, the original follow-up-length-weighted receiver operating characteri

SUBMITTER: Dwyer MG 

PROVIDER: S-EPMC5842310 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature