Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study.

ABSTRACT:

Objective

To investigate whether oral fluoroquinolone use is associated with an increased risk of aortic aneurysm or dissection.

Design

Nationwide historical cohort study using linked register data on patient characteristics, filled prescriptions, and cases of aortic aneurysm or dissection.

Setting

Sweden, July 2006 to December 2013.

Participants

360 088 treatment episodes of fluoroquinolone use (78%ciprofloxacin) and propensity score matched comparator episodes of amoxicillin use (n=360 088).

Main outcome measures

Cox regression was used to estimate hazard ratios for a first diagnosis of aortic aneurysm or dissection, defined as admission to hospital or emergency department for, or death due to, aortic aneurysm or dissection, within 60 days from start o

SUBMITTER: Pasternak B 

PROVIDER: S-EPMC5842359 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature