Dynamics of Colonization of Streptococcus pneumoniae Strains in Healthy Peruvian Children.

ABSTRACT:

Background

Although asymptomatic carriage of Streptococcus pneumoniae (Spn) is common, acquisition of the bacteria is the first step in disease pathogenesis. We examined the effect of introduction of the 7-valent pneumococcal vaccine on Spn carriage patterns in a cohort of Peruvian children.

Methods

We used data from a prospective cohort study that collected monthly nasopharyngeal samples from children under 3 years of age. Spn isolates were serotyped using Quellung reactions, and bacterial density was determined by quantitative polymerase chain reaction. Changes in Spn carriage patterns, including the rate of carriage and number and density of serotypes carried over time, were evaluated before (2009) and after widespread vaccination with P

SUBMITTER: Nelson KN 

PROVIDER: S-EPMC5842394 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature