Mortality and pulmonary outcomes of extremely preterm infants exposed to antenatal corticosteroids.

ABSTRACT:

Background

Antenatal corticosteroids are given primarily to induce fetal lung maturation but results from meta-analyses of randomized controlled trials have not shown mortality or pulmonary benefits for extremely preterm infants although these are the infants most at risk of mortality and pulmonary disease.

Objective

We sought to determine if exposure to antenatal corticosteroids is associated with a lower rate of death and pulmonary morbidities by 36 weeks' postmenstrual age.

Study design

Prospectively collected data on 11,022 infants 22 0/7 to 28 6/7 weeks' gestational age with a birthweight of ≥401 g born from Jan. 1, 2006, through Dec. 31, 2014, were analyzed. The rate of death and the rate of physiologic bronchopulmonary dysplasia by 36 weeks' postmenstrual age w

SUBMITTER: Travers CP 

PROVIDER: S-EPMC5842434 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature