Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database.

ABSTRACT:

Background

Antidepressants are one of the most commonly prescribed medications in young and middle-aged adults, but there is relatively little information on their safety across a range of adverse outcomes in this age group. This study aimed to assess associations between antidepressant treatment and several adverse outcomes in people aged 20-64 years diagnosed with depression.

Methods

We conducted a cohort study in 238,963 patients aged 20-64 years registered with practices across the UK contributing to the QResearch primary care database. Only patients with a first diagnosis of depression were included. Outcomes were falls, fractures, upper gastrointestinal bleed, road traffic accidents, adverse drug reactions and all-cause mortality recorded during follow-up. Cox proporti

SUBMITTER: Coupland C 

PROVIDER: S-EPMC5842559 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature