Comprehensive evaluation of NT5E/CD73 expression and its prognostic significance in distinct types of cancers.

ABSTRACT:

Background

CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. We aimed to provide an overview of the current status of CD73 expression and its relationship with clinicopathlogical features and prognosis in different cancers.

Methods

PubMed, Web of Science, EMBASE and Cochrane library were searched to identify the relevant studies. CD73 expression level in distinct cancers and its relationship with clinicopathlogical characteristics and prognosis were investigated using online database. Meta-analyses were conducted using RevMan v5.0 and STATA v12.0.

Results

Fourteen publications with 2951 cases were included. The incidence of high CD73 expression was 0.50 (95% CI: 0.36-0.63). Data from Oncomine validated that median

SUBMITTER: Jiang T 

PROVIDER: S-EPMC5842577 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature