Physiological and molecular effects of interleukin-18 administration on the mouse kidney.

ABSTRACT:

Background

The cytokine interleukin-18 was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence to suggest that it has non-immunological effects on physiological functions. We previously investigated the potential pathophysiological relationship between interleukin-18 and dyslipidemia, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis, and suggested interleukin-18 as a possible novel treatment for not only these diseases but also for cancer immunotherapy. Before clinical application, the effects of interleukin-18 on the kidney need to be determined. In the current study, we examined the kidney of interleukin-18 knockout (Il18^-/-) mice and the effects of interleukin-18 on the kidney following in

SUBMITTER: Yamanishi K 

PROVIDER: S-EPMC5842592 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature