Large-scale brain organization during facial emotion processing as a function of early life trauma among adolescent girls.

ABSTRACT:

Background

A wealth of research has investigated the impact of early life trauma exposure on functional brain activation during facial emotion processing and has often demonstrated amygdala hyperactivity and weakened connectivity between amygdala and medial PFC (mPFC). There have been notably limited investigations linking these previous node-specific findings into larger-scale network models of brain organization.

Method

To address these gaps, we applied graph theoretical analyses to fMRI data collected during a facial emotion processing task among 88 adolescent girls (n = 59 exposed to direct physical or sexual assault; n = 29 healthy controls), aged 11-17, during fMRI. Large-scale organization indices of modularity, assortativity, and global efficiency were calculated for

SUBMITTER: Cisler JM 

PROVIDER: S-EPMC5842665 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature