Alteration of brain network topology in HIV-associated neurocognitive disorder: A novel functional connectivity perspective.

ABSTRACT: HIV is capable of invading the brain soon after seroconversion. This ultimately can lead to deficits in multiple cognitive domains commonly referred to as HIV-associated neurocognitive disorders (HAND). Clinical diagnosis of such deficits requires detailed neuropsychological assessment but clinical signs may be difficult to detect during asymptomatic injury of the central nervous system (CNS). Therefore neuroimaging biomarkers are of particular interest in HAND. In this study, we constructed brain connectivity profiles of 40 subjects (20 HIV positive subjects and 20 age-matched seronegative controls) using two different methods: a non-linear mutual connectivity analysis approach and a conventional method based on Pearson's correlation. These profiles were then summarized using graph-theore

SUBMITTER: Abidin AZ 

PROVIDER: S-EPMC5842750 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature