Connectome-wide investigation of altered resting-state functional connectivity in war veterans with and without posttraumatic stress disorder.

ABSTRACT: Altered resting-state functional connectivity in posttraumatic stress disorder (PTSD) suggests neuropathology of the disorder. While seed-based fMRI connectivity analysis is often used for the studies, such analysis requires defining a seed location a priori, which restricts search scope and could bias findings toward presupposed areas. Recently, a comprehensive exploratory voxel-wise connectivity analysis, the connectome-wide association approach, has been introduced using multivariate distance matrix regression (MDMR) for resting-state functional connectivity analysis. The current study performed a connectome-wide investigation of resting-state functional connectivity for war veterans with and without PTSD compared to non-trauma-exposed healthy controls using MDMR. Thirty-five mal

SUBMITTER: Misaki M 

PROVIDER: S-EPMC5842755 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature