The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers.

ABSTRACT:

Background

C1q TNF related protein 3 (CTRP3) is a relatively novel hormonal factor primarily derived from adipose tissue and has anti-diabetic properties. To determine if CTRP3 could play a role in early childhood development, the purpose of this study was to establish the presence of CTRP3 in breast milk (BM) and to determine whether CTRP3 levels were correlated with pregravid obesity status of the mother.

Methods

Breast milk was collected from breast-feeding mothers who had a pregravid body mass index (BMI) classification of normal weight (BMI 18-25 kg/m², n = 23) or obese (BMI > 30 kg/m², n = 14). Immunoprecipitation followed by immunoblot analysis confirmed the presence of CTRP3 in BM. The concentration of CTRP3 in BM samples was deter

SUBMITTER: Kwon MR 

PROVIDER: S-EPMC5842766 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature