Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population.

ABSTRACT:

Background

Ethnic differences exist in the frequencies of genetic variations that contribute to the risk of common disease. This study aimed to analyse the distribution of several genes, previously associated with susceptibility to type 2 diabetes and obesity-related phenotypes, in a Kazakh population.

Methods

A total of 966 individuals belonging to the Kazakh ethnicity were recruited from an outpatient clinic. We genotyped 41 common single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes in other ethnic groups and 31 of these were in Hardy-Weinberg equilibrium. The obtained allele frequencies were further compared to publicly available data from other ethnic populations. Allele frequencies for other (compared) populations were pooled from the haplo

SUBMITTER: Sikhayeva N 

PROVIDER: S-EPMC5842777 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature