Abnormalities in gray matter volume in patients with borderline personality disorder and their relation to lifetime depression: A VBM study.

ABSTRACT:

Background

Structural imaging studies of borderline personality disorder (BPD) have found regions of reduced cortical volume, but these have varied considerably across studies. Reduced hippocampus and amygdala volume have also been a regular finding in studies using conventional volumetric measurement. How far comorbid major depression, which is common in BPD and can also affect in brain structure, influences the findings is not clear.

Methods

Seventy-six women with BPD and 76 matched controls were examined using whole-brain voxel-based morphometry (VBM). The hippocampus and amygdala were also measured, using both conventional volume measurement and VBM within a mask restricted to these two subcortical structures. Lifetime history of major depression was assessed using struc

SUBMITTER: Aguilar-Ortiz S 

PROVIDER: S-EPMC5842882 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature