Thrombospondin-2 predicts response to treatment with intravenous immunoglobulin in children with Kawasaki disease.

ABSTRACT:

Objective

To investigate the predictive value of thrombospondin-2 (TSP-2) in assessing the response to intravenous immunoglobulin (IVIG) in children with acute Kawasaki disease (KD).

Methods

This was a cohort study with controls. 71 children with KD were recruited as the case group, including IVIG non-responder (n=17) and IVIG responder (n=54), and healthy children (n=27) and febrile children (n=30) were used as control groups. ELISA was used to measure plasma TSP-2 and TSP-1 levels. The rank-sum test was used to compare groups of non-normally distributed data. Predictive value was evaluated through the receiver operating characteristic (ROC) curve.

Results

Compared with the control groups, the plasma TSP-2 levels in acute KD were significantly elevated (TSP-2: 31.00

SUBMITTER: Yang S 

PROVIDER: S-EPMC5842996 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature