Changes in survival and neurodevelopmental outcomes of infants born at <25 weeks' gestation: a retrospective observational study in tertiary centres in Japan.

ABSTRACT:

Objective

To evaluate changes in the outcomes of infants born at <25 weeks' gestation in the past decade.

Design

Retrospective observational study.

Settings

A multicentre database of the Neonatal Research Network, Japan.

Patients

A total of 3318 infants born at 22-24 weeks' gestation between periods 1 (2003-2007) and 2 (2008-2012) from 52 tertiary centres.

Main outcome measures

We compared death and neurodevelopmental impairments (NDIs) at 3 years of age, including cerebral palsy (CP), visual impairments (VIs), hearing impairments (HIs) and the developmental quotient (DQ) of the Kyoto Scale of Psychological Development test <70, between two periods using multivariate logistic regression analyses adjusted for the centre, gender, multiple gestation, matern

SUBMITTER: Kono Y 

PROVIDER: S-EPMC5843009 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature