Nuclear receptor and VEGF pathways for gene-blood lead interactions, on bone mineral density, in Korean smokers.

ABSTRACT: Osteoporosis has a complex etiology and is considered a multifactorial polygenic disease, in which genetic determinants are modulated by hormonal, lifestyle, environmental, and nutritional factors. Therefore, investigating these multiple factors, and the interactions between them, might lead to a better understanding of osteoporosis pathogenesis, and possible therapeutic interventions. The objective of this study was to identify the relationship between three blood metals (Pb, Cd, and Al), in smoking and nonsmoking patients' sera, and prevalence of osteoporosis. In particular, we focused on gene-environment interactions of metal exposure, including a dataset obtained through genome-wide association study (GWAS). Subsequently, we conducted a pathway-based analysis, using a GWAS dataset, to

SUBMITTER: Lee HS 

PROVIDER: S-EPMC5843219 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature