A common copy-number variant within SIRPB1 correlates with human Out-of-Africa migration after genetic drift correction.

ABSTRACT: Previous reports have proposed that personality may have played a role on human Out-Of-Africa migration, pinpointing some genetic variants that were positively selected in the migrating populations. In this work, we discuss the role of a common copy-number variant within the SIRPB1 gene, recently associated with impulsive behavior, in the human Out-Of-Africa migration. With the analysis of the variant distribution across forty-two different populations, we found that the SIRPB1 haplotype containing duplicated allele significantly correlated with human migratory distance, being one of the few examples of positively selected loci found across the human world colonization. Circular Chromosome Conformation Capture (4C-seq) experiments from the SIRPB1 promoter revealed important 3D modification

SUBMITTER: Royo JL 

PROVIDER: S-EPMC5843225 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature